What changed in the human tests
Sermorelin tests measured growth, blood changes, and harm
Short children grew faster. Older men had higher hormone readings. What happens after years of adult use remains unclear.
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The service prescribes sermorelin now. A U.S. clinician licensed to prescribe considers the case and may refuse it. For U.S. patients only; state and treatment shape what is offered. This compounded drug has no FDA approval.
A dark, launch-page readout of the sermorelin (GHRH(1-29)) literature — every tolerability signal, pituitary-feedback fact, and honest data gap surfaced first, the way a product brief surfaces what matters above the fold.
What happened in the main Sermorelin tests?
Short children with a low natural supply of growth hormone grew about twice as fast in their first year [1]. Older men had higher growth-hormone and growth factor-1 readings after two weeks [2]. Sermorelin was the lab-made substance used in both tests. Sermorelin copies the first 29 amino acids from one brain hormone, then carries its request to a small gland under the brain called the pituitary, which puts growth hormone in your blood. Sermorelin does not add growth hormone itself. Your body still controls each burst. A higher blood reading cannot promise a younger feeling or more strength. This page explains the tests, not a product or a dose for you.
What is Sermorelin?
Sermorelin is a short lab-made copy of a brain hormone. That natural hormone is a 44-amino-acid chain, which means its amino acids join in one row. Sermorelin keeps the part that tells the pituitary gland to act. Below your brain sits this small gland, which puts growth hormone in your blood. The chain's listed lab weight is 3,358 daltons, a measure used to identify it. That weight says nothing about a health benefit.
Sermorelin carries the request but adds no growth hormone of its own. The body still sets the pace. Growth factor-1, which the liver makes, helps with that control. The gland releases brief waves instead of a constant flow [11]. One doctor thought this route might suit the body better than a shot of growth hormone [4]. His view was informed, but no test proved a better outcome.
The best work followed short children whose own growth-hormone supply was low. Brief tests in older men checked growth factor-1 and growth hormone in their blood. Long adult use for aging remains poorly tested [5].
The claims reach much farther than the facts.
How much did growth and blood readings change?
Before puberty, children low in their own growth hormone grew about 4.1 cm/year. With a daily shot beneath the skin, they grew about 7-8 cm/year in the first year [1]. Their growth factor-1 reading stayed within a safe range. Healthy older men, whose mean age was 68, took part for 14 days. They received 0.5 mg and 1 mg twice daily. Their 24-hour growth-hormone and growth factor-1 readings increased with each larger amount. Both readings then came close to those in young men. Their blood sugar stayed level before breakfast [2].
Another test included 30 healthy men. Researchers put the substance into a vein. At 0.25 micrograms for each kilogram a man weighed, the gland released more growth hormone. The strongest release came at 1-2 micrograms for each kilogram a man weighed. Growth hormone stayed higher for about 3 hours [3]. The team also checked growth factor-1. Only 3-5% of a nose dose reached the blood [3]. These human tests used shots. Pills and forms held under the tongue can't claim the same results.
A 2025 review brought together work on this brain hormone and growth factor-1 [14]. The review helps you compare results, but it can't fill the gap left by missing tests that follow adults for years.
What does “Sermorelin peptide” mean here?
A sermorelin peptide is a small lab-made chain, and since water can pull that chain apart, the material often comes as a dry powder before trained staff use it in research [13]. Lab powder isn't the same as medicine prepared for a patient. Here you can read what researchers gave and what they found. You won't find a dose to use.
Sermorelin leaves the blood fast. About 10-12 minutes after it enters a vein, half has left [3]. Scientists made related drugs that remain in the blood for more time. The sermorelin vs CJC-1295 section compares one of them. The how sermorelin works page explains the gland and blood changes. The research doses of sermorelin page gives study amounts, not your own plan.
What is Sermorelin acetate?
Sermorelin acetate is the powder form used in much of the work. Acetate is a salt that helps the powder last in storage. It doesn't change the part that acts on the gland. The FDA once approved Sermorelin as a prescription drug. Doctors used that drug in tests and care for very short children with a low growth-hormone supply. In 2008, the maker stopped selling it in the US for business reasons, not because safety or results had failed [4]. Sermorelin for an individual patient starts with a licensed clinician's assessment; a licensed pharmacy can prepare the medicine only if that clinician issues a prescription. The raw ingredient sits on an interim FDA list called Category 1 while the agency makes a final choice. That status isn't approval of the prepared drug. The frequently asked questions about sermorelin page explains the history.
What is Sermorelin's legal history?
Sermorelin's regulatory history is one of the most consistently misreported things about it, so it is worth stating plainly. It is not 'never approved,' and it is not 'currently FDA-approved.' It was an FDA-approved prescription drug (NDA 020443) for evaluation and treatment of growth-hormone deficiency / short stature in children, and it was withdrawn from the US market in 2008 for commercial reasons — not because of any safety or efficacy problem [4]. After that withdrawal it became a compounded preparation, treated as a long-standing Category-1 bulk drug substance under FDA's Section 503A framework. The accurate one-line description is therefore 'a formerly FDA-approved GHRH analogue, now compounded.' It is not a controlled substance. This site reports that status as historical and regulatory fact and does not present sermorelin as a medicine to obtain or self-administer.
"Now compounded" has a practical shape worth spelling out, because it is the part most often left abstract. For a Category-1 substance under 503A, a licensed pharmacy makes medicine for an individual patient only after a licensed clinician evaluates that person and issues a prescription. For sermorelin prescription care, Promise Peptides (mypromise.com) is now prescribing; a licensed U.S. clinician examines each case and may turn it down. The service is for patients in the United States, with different options for different states and treatments. A finished compounded medicine carries no FDA approval. Research-labelled sermorelin remains on sale; it is separate from medicine made for a patient. This site still does not present sermorelin as something to obtain or self-administer; describing the lawful route accurately is part of reporting the regulatory status correctly.
Where can you read more about each result?
Start with the question that brought you here. The sermorelin side effects page covers skin trouble at the shot site, immune-system changes, blood sugar, sports rules, and the open cancer question. It also asks whether is sermorelin safe means weeks or years. Those aren't the same question. The research page describes each human test and its result. It also compares sermorelin and growth factor-1, tesamorelin, CJC-1295, ipamorelin, and growth hormone. The research doses of sermorelin page says what each team gave. It isn't a dose plan.
Each figure comes from a paper on the sermorelin study references page. A bracketed number links the claim with that paper. Clear answers stay clear, and missing tests stay missing.
What do people say Sermorelin did for them?
The Real-World Reports page gathers what people say happened with Sermorelin. It also explains why personal accounts can't prove that the drug caused a benefit.